克罗米胺对男性低促性腺素性功能减退症有效

明尼阿波利斯（路透社保健海外版）1月四日新闻报道：据发表在12月出海外版的《生育与不孕》杂志的一项报告指出克罗米醇对大多低促性腺亦同性功用减退的未成年病人有利。来自伯明翰新泽西大学的该报告的第一所写Scott J. Whitten教授在接纳路透路透社采访时知道：“病变或应予HH病人在接纳不作为性更大和更为昂贵的病人（例如注射促性腺激亦同类）前展开4个月的克罗米醇试验性病人是有利的。”Whitten教授和同事深入研究了克罗米醇对10名HH未成年病人（HH是导致未成年不孕的少见环境因亦同）有否直接。报告称作克罗米醇病人1年后，4名卡尔曼(宰)综合征病人中只有一名病人的卵子浓度减少而全输卵管功用减退症病人的卵子不足症状均未得到改善。相反，该报告指出3名成年病症的病变HH未成年病人经过3个月克罗米醇的病人卵子浓度有了明显减少。目前为止该组病人已有两名恢复了生育能力。Whitten教授知道：“除非对克罗米醇病人未反应，我们不会因为副作用停止对病人使用该药物。”最后所写说明了知道：“因为条件更少，对HH病人促性腺激亦同镇静剂和克罗米醇的随机深入研究难以展开，然而来进行多前传的符合选取国际标准对病人展开国际国际标准不太可能协助进一步验证克罗米醇恢复未成年低生育能力的直接性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色幻想

编辑： 张靖